Precodil 5mg (20pcs)

Precodil is a steroid. It is used for treatment of wide variety of medical conditions such as severe allergic reactions, asthma, rheumatic disorders and skin and eye disorders. It provides relief by preventing the release of substances that cause inflammation and by suppressing the immune system. Precodil should be taken with food to avoid an upset stomach. It should be swallowed whole with water at the same time(s) each day. Your doctor will decide the dose and how often you should take them. This may change from time to time depending on how well they are working. You should take this medicine regularly to get the most benefit, even if you feel fine. The most common side effect of this medicine is reduction in bone density, weight gain, mood changes, upset stomach, and behavioural changes. Talk to your doctor if these bother you or do not go away. Taking Precodil can also make it harder for you to fight off infections. Tell your doctor if you have any signs of infection such as fever or sore throat. Let your doctor know about any medical issues you have, especially poor blood circulation, diabetes and immune system problems and about other medicines you are taking (particularly steroids).

Uses of Precodil

• Severe allergic reactions
• Allergic conditions
• Asthma
• Rheumatic disorder
• Skin disorders
• Eye disorders
• Nephrotic syndrome

Side effects of Precodil

Common

• Behavioural changes
• Edema (swelling)
• Glucose intolerance
• Increased appetite
• Mood changes
• High blood pressure
• Weight gain

How to use Precodil

Take this medicine in the dose and duration as advised by your doctor. Dissolve it in a glass of water before taking it. Precodil may be taken with or without food, but it is better to take it at a fixed time.

How Precodil works

Precodil is a steroid which works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.

Quick Tips

• Wysolone 5 Tablet DT helps treat inflammation, severe allergies, flare-ups of ongoing illnesses, and many other medical problems that require either reduction of inflammation or suppression of the immune system.
• Do not use it more often or for longer than advised by your doctor.
• Take it with food to avoid an upset stomach.
• Wysolone 5 Tablet DT can make it harder for you to fight off infections. Notify your doctor if you have any signs of infection such as a fever or sore throat.
• Side effects such as mood changes or stomach problems can happen when you start taking Wysolone 5 Tablet DT. Inform your doctor if this bothers you.
• Do not stop taking Wysolone 5 Tablet DT suddenly without talking to your doctor first as it may worsen your symptoms.

Brief Description

Indication

Rheumatoid arthritis, Multiple sclerosis, Allergic and inflammatory disorders, Nephrotic syndrome, Idiopathic thrombocytopenic purpura, Joint inflammations, Moderate to severe asthma, Infantile spasms

Administration

Should be taken with food.

Adult Dose

Oral Allergic and inflammatory disorders Adult: 5-60 mg daily in 2-4 divided doses. Maintenance: 2.5-15 mg daily. Withdrawal should be gradual after long-term therapy. Poorly controlled, moderate to severe asthma, COPD Adult: Patients with at least 2 exacerbations/yr requiring oral corticosteroids: 40-60 mg daily in 1-2 divided doses; usually given as a short course treatment over 10-14 days until symptom resolution and patient achieves a peak expiratory flow (PEF) of at least 80% of his or her personal best. Rheumatoid arthritis Adult: Initially, 5-7.5 mg daily, adjusted as necessary. Elderly: 5 mg daily. Multiple sclerosis Adult: 200 mg daily for 1 wk followed by 80 mg every other day for 1 mth. Bells Palsy 60 mg PO qDay for 5 days; then taper down by 10 mg daily for 5 days for total duration time of 10 days

Child Dose

Inflammation 0.1-2 mg/kg/day PO in single daily dose or divided q6-12hr; not to exceed 80 mg/day Acute Asthma 1-2 mg/kg/day in single daily dose or divided q12hr for 3-5 days Nephrotic Syndrome First 4 weeks: 60 mg/m²/day or 2 mg/kg/day PO divided q8hr until urine is protein free for 3 consecutive days; not to exceed 28 days; dose not to exceed 80 mg/day Subsequent 4 weeks: 40 mg/m² or 1-1.5 mg/kg PO every other day; not to exceed 80 mg/day Maintenance in frequent relapses: 0.5-1 mg/kg/dose PO every other day for 3-6 months Idiopathic thrombocytopenic purpura Child: 1-10 yr: 1-2 mg/kg daily (max: 14 days) or 4 mg/kg daily (max: 4 days).

Contraindication

Live vaccines; herpes simplex keratitis, systemic infections.

Mode of Action

Prednisolone decreases inflammation by inhibition of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It suppresses the immune system by reducing the activity and production of the lymphocytes and eosinophils.

Precaution

Patients with hypothyroidism, cirrhosis, ulcerative colitis, CHF, convulsive disorders, thrombophlebitis, peptic ulcer, elderly. DM, hypertension, psychological disturbances, osteoporosis; pregnancy, lactation. Adrenal suppression and infection. May cause irreversible growth retardation, glaucoma, corneal perforation. Lactation: Excreted in breast milk; use caution

Side Effect

Acne,Adrenal suppression,Delayed wound healing,Diabetes mellitus,GI perforation,Glucose intolerance,Hepatomegaly,Hypokalemic alkalosis,Increased transaminases,Insomnia,Menstrual irregularity,Myopathy,Neuritis,Osteoporosis,Peptic ulcer,Perianal pruritus,Pituitary adrenal axis suppression,Pseudotumor cerebri (on withdrawal),Psychosis,Seizure,Ulcerative esophagitis,Urticaria,Vertigo,Weight gain Potentially Fatal: Acute adrenal insufficiency precipitated by infection, trauma or surgery in patients on long-term therapy or following cessation of such therapy. CV collapse following rapid IV injection.

Interaction

Efficacy may be reduced by phenytoin, phenobarb, rifampicin. Corticoids may reduce the effects of diuretics, hypoglycaemics, anticholinesterases, salicylates.